Andriol Testocaps

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Description

Description

Pharmacological effect

Testosterone is an endogenous hormone necessary for normal development of male genitalia and secondary sex characteristics, maintenance of normal function of testes, prostate and seminal vesicles, maintenance of libido and potency. The use of the drug for the treatment of hypogonadism in men leads to a clinically significant increase in the plasma concentration of testosterone, dihydrotestosterone and androstenedione and a decrease in sex hormones binding globulin (SHGG). In men with primary hypogonadism (hypergonadotropic), the use of the drug leads to the normalization of the concentration of gonadotropin.

Pharmacokinetics

After ingestion, a large part of testosterone undecanoate with the lipophilic solvent is absorbed in the small intestine and enters the lymphatic system, thus avoiding the primary passage through the liver. With the absorption of Testosterone undecanoate is partially reduced with the formation of dihydrotestosterone undecanoate. From the lymphatic system it enters the plasma. In plasma and tissues, as a result of hydrolysis of testosterone undecanoate and ditrotestosterone undecanoate, the natural male sex hormones testosterone and dihydrotestosterone are released.
A single administration of 80-160 mg Andriol TC results in a clinically significant increase in total plasma testosterone concentration, Cmax is approximately 40 nmol/L and is reached 4-5 hours after administration.The increase in testosterone concentration is retained, but at least for 8 hours. It is excreted mainly with the urine in the form of conjugates (etiocholanolone and androsterone).

Dosage

The dose is selected individually depending on the clinical effect.
As a rule, the initial dose is 120-160 mg / day for 2-3 weeks, maintaining a dose of 40-120 mg / day.
The drug should be taken with food, washed down with a small amount of water. The capsules should be swallowed whole and not liquid. It is advisable to take half the dose in the morning and the second half in the evening. If an odd number of capsules are taken, a higher dose should be taken in the morning.

Andriol Testocaps

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