Pedal 20

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Description

Description

Normalizes the final differentiation of cells, inhibits the proliferation of the epithelium of the ducts of the sebaceous glands, the formation of debris, facilitates evacuation. Reduces the production and facilitates the release of sebum.
When given, absorption is variable, bioavailability is low and variable , Ingestion with food increases bioavailability by a factor of 2. Tmax – 2-4 hours binding to blood plasma proteins (mainly with albumin) – 99.9%. Metabolized with the formation of three main biologically active metabolites – 4-oxo-isotretinoin (main metabolite), tretinoin and 4-oxo-retinoin, and less important metabolites, including glucuronides. Since isotretinoin and tretinoin in vivo are reversible into each other Isotretinoin (Accutane) tretinoin metabolism is associated with isotretinoin metabolism. 20-30% of the isotretinoin dose is metabolized by isomerization. In the pharmacokinetics of isotretinoin in man, the enterohepatic circulation may play an important role. In vitro studies have shown that the metabolism of isozretinoin involves the CYP2C8, CYP2C9, CYP3A4 and CYP2B6 isozymes of cytochrome P450. T1 / 2 isotretinoin – 19 hours, 4-oxo-isoretinoin – 29 hours. It is excreted by the kidneys and with bile in approximately equal amounts.

Accutane (isotretinoin) should not be used by patients who are pregnant or may become pregnant.There is an extremely high risk of serious birth defects if pregnancy occurs while taking any amount, even for short periods, of Accutane (isotretinoin). Any fetus exposed during pregnancy can potentially be affected. There is no definite way to determine if an exposed fetus is affected.

Birth defects documented after exposure to Accutane (isotretinoin) include abnormalities of the face, eyes, ears, skull, central nervous system, cardiovascular system, thymus, and parathyroid glands. Cases of IQ scores below 85 with or without other abnormalities have been reported. There is an increased risk of spontaneous abortion and premature births have been reported.

Pedal 20

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