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Maxi-Fen-10, is a good inhibitor of the processes involved in the regeneration of testosterone into estrogen, blocking peripheral estrogen receptors. According to the chemical composition, Maxi-Fen-10 is and is a configuration derived from triphenylethylene. This drug belongs to the class of sex hormones. It was created for health and medical use Tamoxifen get breast cancer and other cancers in a weak half of humanity.

Dosage and direction

Tablets are given inside without chewing, with a small amount of water. If two or more tablets are prescribed per day, they can be taken in one or two intakes.
The recommended daily dose of tamoxifen for adults is 20 mg. In the case of widespread forms of the disease, the doses can be increased up to 30-40 mg per day. The maximum daily dose of tamoxifen is 40 mg. Objectively, the treatment effect is usually observed after 4-10 weeks of treatment, but in the case of bone metastases, the effect can only be observed after several months of treatment.
The duration of treatment with tamoxifen is determined by the severity and course of the disease. Usually the treatment is long. '
In the treatment of elderly patients or patients with hepatic or renal insufficiency, no dosage adjustment is necessary.

Side effect

Disorders of the blood system: rarely – thrombocytopenia (the number of platelets decreases to 80,000 – 90,000 / mm3), leukopenia, Very rarely – neutropenia, pancytopenia. Visual disorders: visual acuity, retinopathy, keratopathy, cataract.These effects are likely to be dose and duration dependent and may be partially reversible upon discontinuation of tamoxifen therapy.
Endocrine Disorders: Due to the anti-estrogenic effects of tamoxifen, adverse side effects such as hot flashes, abnormal vaginal bleeding, menstrual irregularities, vaginal discharge, and itching of the sexual organs are most commonly noted. Also, possible water retention in the body, nausea, vomiting. Transient acceleration of tumor growth, dizziness, rash, fatigue, headache are less common. In men, impotence or loss of libido is possible. In isolated cases, anorexia, dyspnoea, constipation, diarrhea, convulsions of the legs, depression, alopecia or intense hairiness are observed. In premenopausal women, it is possible to stop menstruation, as well as the sometimes reversible cystic ovarian edema. In a small number of patients with bone metastases, hypercalcaemia develops at the start of treatment. Possibly an initial increase in pain in bones and tumors, as well as the spread of erythema around skin lesions, which may be evidence of the presence of land
Singing effect. It is also possible to increase existing skin lesions or the appearance of new ones.
Both benign and malignant neoplasms with terapyatemoxifene are associated with an increased risk of proliferative changes in the endometrium, particularly endometrial hyperplasia, polyps, endometriosis and, in rare cases, cancer of the endometrium. endometrium. The likelihood of developing endometrial cancer increases with the duration of tamoxifen treatment and about 2-3 times the likelihood of endometrial cancer in women who did not receive the drug.However, the clinical benefit of using tamoxifen in the treatment of female breast cancer outweighs the possible risk of development of neoplastic endometrial structures.
Vascular disorders: quite often – thrombosis, Very rarely – pulmonary embolism. With the parallel use of tamoxifen and cytotoxic drugs, the risk of thromboembolic complications increases.
Immune system disorders: rarely – hypersensitivity reactions including rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, bullous pemphigoid.
Disorders of the hepatobiliary system: impaired activity of hepatic enzymes, In isolated cases – fatty infiltration of the liver, cholestasis, hepatitis.
Most reported side effects are reversible and can be reduced or eliminated by lowering the dose.



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