Frusenex

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Description

Description

Furosemide is a powerful diuretic, one of the strongest diuretics. In fact, the drug is not doping, but widely used in unofficial sports medicine, it is included in the list of drugs prohibited for registration by athletes. Despite this, furosemide remains one of the most popular means in sports. Read the pharmacological effects of Furosemide (Lasix) will be interesting and understandable only for professionals, so we will get acquainted in general terms.

dosage

Dosage and dosage regimens are set individually depending on the degree of disruption of the value of the water-electrolyte balance of glomerular filtration. Then necessary, depending on the dose adjustment, the severity of the patient's disease, the size of urinary excretion. Usually the drug is administered in the form of a tablet, but if this is impossible or we are talking about urgent conditions, the drug is administered intravenously, the introduction of Lasix should not be less than 1.5-2 minutes.

With moderate severity of edema syndrome initially, the dose of Lasix is ​​20-80 mg or 20-40 mg orally intramuscularly or intravenously, with little effect the dose can be increased to 40 mg when administered orally and 20 mg when administered by Lasix injection. Dose increase cannot be earlier than 6-8 hours after receiving an initial oral dose no earlier than 2 hours after parenteral administration. A dose adjustment is made until the diuresis is sufficient.A single coordinated dose can therefore be administered once or twice a day. The maximum effect of Lasix can occur when the drug is administered 2-4 times per week.
For children, the dose depends on the child's weight and how Lasix is ​​given. The initial dose of oral administration of 2 mg / kg, followed by administration by injection – 1 mg / kg. The dose can then be increased to 2 mg/kg orally and 1 mg/kg for parenteral administration. Dose increase cannot be earlier than 6-8 hours after receiving an initial oral dose no earlier than 2 hours after parenteral administration.

The combined treatment of hypertension, the dose of Lasix is ​​usually 80mg/day, preferably the daily dose is divided into two stages. It is not recommended to further increase the dose, other antihypertensives should be added if they have little effect.
With intravenous pulmonary edema, 40 mg is administered, with little effect in 20 minutes, another 20-40 mg can be introduced.
When performing forced diuresis, 20-40 mg of Lasix is ​​added to a solution for intravenous infusion. Subsequently, the dose of Lasix may be adjusted depending on residual water electrolytes and the patient's condition.

Side effects

When applied in high doses of Lasix, the bcc (circulating blood volume) decreases, thus developing possible blood clots and thrombosis. A frequent side effect is the development of an electrolyte imbalance of water: alkalosis (including the improvement of metabolic alkalosis diabetes), deficiency of sodium, chlorine, calcium, potassium , Violation of the biochemical properties of blood: increased creatinine, cholesterol, triglycerides, uric acid (explosive gout), glucose (especially diabetes).

Allergic reactions range from cutaneous manifestations (purpura, dermatitis, pruritus, erythema) to anaphylactic shock.
You rarely have blood diseases: leukopenia, eosinophilia, haemolytic changes, agranulocytosis, thrombocytopenia.
In low birth weight or premature babies, using Lasix in the first weeks of life may cause the ductus arteriosus to crack.

Contraindications

Contraindications are expressed electrolyte imbalances, intolerance to furosemide or any other component of the Lasix preparation, anuria, dehydration, absence of BCC, hepatic coma at any stage of pregnancy up to 12 weeks and lactation.
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