Description
Description
This process is mediated by the release of nitric oxide from nerve endings and endothelial cells of the corpora cavernosa. Nitric oxide stimulates cGMP synthesis in smooth muscle cells. The accumulation of cGMP leads to muscle relaxation and increased blood flow to the corpora cavernosa. PDE5 inhibition with Tadalafil is accompanied by an increase in the amount of cGMP and an increase in erectile function. As sexual stimulation is necessary to initiate the process of local nitric oxide release, PDE5 inhibition by tadalafil is ineffective in the absence of stimulation.
The active ingredient Tadalafil was developed and received by the British pharmaceutical company Elly Lilly. This preparation is a means for the treatment of various diseases of male erection. Tadalafil works by relaxing the blood vessels which increases blood flow to the tissues of men's penis which is good erection. A British company is marketing drugs containing tadalafil as an active component called Cialis.
Effects and therapeutic effects
Tadalafil is a drug that improves male erection. The drug has the ability to influence the main reactions, a unique process that forms sexual arousal and brings the penis into an erect state. Usually, when a man is aroused, the vessels of the penis increase significantly, there is a large influx of blood volume, which makes the penis dense, that is, an erection occurs (or, in mother tongue, he 'rises').During various erectile dysfunctions, there is a shortage of blood in the vessels of the penis. Tadalafil is a drug that increases blood circulation in the penis, resulting in a stable and good erection. Enhanced penile blood circulation is due to the expansion of blood vessels under the influence of special substances – cGMP. Phosphodiesterase-5 – but the cGMP enzyme is rapidly destroyed special (PDE – 5). Tadalafil inhibits (slows down) the functioning of PDE-5 and therefore does not break down cGMP but works over a long period of time by relaxing blood vessels and helping to fill the penis with blood for the development of an erection normal. . Thus, its clinical effect is Tadalafil vasodilator or vasodilator. However, tadalafil has no effects on its own, to produce its effects, sexual stimulation and natural sexual arousal must be. The drug can not only expand the blood vessels, fill them with blood and thus make the penis erect. The fact that cGMP requires penis expansion vessels, is created under the influence of nitric oxide (NO). A nitric oxide precursor is only released when male sexual arousal begins. It is normal for sexual arousal to cause impulses to be sent to the respective centers in the spinal cord and the brain, which are reverse fibers along the nerves to transmit a command to release nitric oxide. So, the release of nitric oxide leads to the availability of cGMP, which is direct and dilates the blood vessels and makes the penis erect. A Tadalafil can only increase and prolong the action of cGMP, which would be formed by nitric oxide under the influence of natural sexual arousal.
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